Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer

(The Wistar Institute) Researchers at the Wistar Institute have found multiple receptors on the outside of the body’s killer immune system cells which they believe can be selectively targeted to keep the cells in superb infection and disease-fighting condition. In a study published online Nov. 30 in Nature Immunology, the researchers describe their discovery of [...]

Combining targeted therapy drugs may treat previously resistant tumors

(Massachusetts General Hospital) A team of cancer researchers from several Boston academic medical centers has discovered a potential treatment for a group of tumors that have resisted previous targeted therapy approaches. In their Nature Medicine report, receiving early online release, the investigators report that combining two different kinase inhibitors — drugs that interfere with [...]

Prescription for patient safety

(Economic & Social Research Council) A major reform of the way that NHS hospitals pay for legal liability insurance has led to improvements in patient safety, according to research funded by the Economic and Social Research Council. Offering discounts on insurance premiums to hospitals that meet certain targets has led to falls in MRSA infection [...]

New statistical model could help reduce breast-lesion biopsies

(Fred Hutchinson Cancer Research Center) A new method of characterizing breast lesions found during an MRI exam could result in fewer biopsies of benign tumors with the benefits of reduced pain and expense for patients and providers, according to a paper that will be presented today at the annual meeting of the Radiological Society of [...]

Electric Fields Clean Up Bioreactors

Researchers from EKB Technology - a spinout joint venture between the University of Oxford and C-Tech Innovation - have announced positive results from an elegant method of improving mammalian cell bioreactors. Bioreactors are used to manufacture proteins for medicines, and the researchers have show that a mild electric field can successfully extract unwanted [...]

Lilly Withdraws Application For Additional U.S. Indication For Cymbalta(R) For Chronic Pain

Eli Lilly and Company (NYSE: LLY) has withdrawn its supplemental New Drug Application (sNDA) from the U.S. Food and Drug Administration (FDA) for Cymbalta(R) (duloxetine HCl) for the management of chronic pain. Lilly plans to resubmit the application in the first half of 2009, adding data from a recently completed positive study in chronic [...]

Women Smokers’ Longevity Cut By 14.5 Years Because Of Smoking

One in every five adult women in the United States still smokes, even though smoking takes an average of 14.5 years off their lives, says the American College of Obstetricians and Gynecologists (ACOG). ACOG said that approximately 438,000 men and women in the USA die prematurely as a result of smoking directly or [...]

Nplate(TM) (Romiplostim) Receives Positive Opinion For Marketing Authorisation In The European Union

Amgen (Nasdaq: AMGN) announced that the European Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion recommending marketing authorisation for Nplate(TM) (romiplostim) in the European Union (EU). The CHMP recommends Nplate for adult chronic immune (idiopathic) thrombocytopenia purpura (ITP) splenectomised patients who are refractory to other treatments (e.g. corticosteroids, immunoglobulins).

Schering Plough Reports Preladenant Meets Primary Endpoint In Phase II Dose-Finding Trial For Parkinson’s Disease

Schering-Plough Corporation (NYSE: SGP) reported that preladenant, its novel and selective adenosine2a receptor antagonist, met the primary endpoint in a Phase II dose-finding trial in patients suffering from moderate to severe Parkinson’s disease experiencing motor fluctuations and abnormal involuntary movements (dyskinesias). The trial results were presented at the company’s 2008 R&D Update meeting being hosted [...]

New Phase III Study Of Avastin In Advanced Breast Cancer Meets Its Primary Endpoint Of Increasing The Time Patients Live

Third study confirming the benefit of Avastin in breast cancer shows that Avastin can be effectively combined with commonly used chemotherapies Roche announced that the Avastin study RIBBON-1 met its primary endpoint of increasing the time women with breast cancer lived without their disease advancing (known as progression-free survival) compared to chemotherapy [...]