Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer

(Cincinnati Children’s Hospital Medical Center) A malfunction that causes instability in people with the blood disorder Fanconi anemia may put them at high risk for squamous cell carcinomas linked to human papillomavirus, according to a study posted ahead of print by Oncogene. Researchers led by Cincinnati Children’s Hospital Medical Center report breakdown of a cell signaling pathway for the FA complex triggers cellular abnormalities, when then are made worse by HPV genes in skin cells.


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