Tracking the molecular pathway to mixed-lineage leukemia

(Whitehead Institute for Biomedical Research) The MLL-AF4 fusion protein, which causes the blood cancer called mixed-lineage leukemia, binds to several genes responsible for early blood cell development. MLL-AF4 also alters the chromatin proteins associated with these genes, a state that is associated with cancer and leukemia progression. Patients with mixed-lineage leukemia have a very poor [...]

Proactive care saves lives of seniors, study finds

(Oregon Health & Science University) Can a patient-centered, care management program utilizing nurse care managers and interdisciplinary teams, supported by electronic tracking and care coordination systems reduce the rate of deaths and hospitalizations among chronically ill older adults? The answer, based on a three-year study involving more than 3,400 chronically ill seniors led by [...]

Single virus used to convert adult cells to embryonic stem cell-like cells

(Whitehead Institute for Biomedical Research) Adult cells, from both humans and mice, can be converted into embryonic stem cell-like cells using a single virus to insert four reprogramming genes into the cells’ genomes. Previous reprogramming approaches have relied on four separate viruses, one virus for each gene, to deliver the genes to cellular nuclei. Because [...]

Electronic Laboratory Reporting May Help Speed Case Reporting of Notifiable Diseases

According to an analysis of Florida reporting from 2002 to 2006, ELR may potentially speed case reporting of notifiable disease and facilitate disease control activities. Medscape Medical News

Nifedipine May Not Prevent Premature Births

A prospective, randomized study showed no benefit vs placebo for maintenance tocolysis with nifedipine, a widely used drug after arrested preterm labor to prevent premature births. Medscape Medical News

Racial Disparities Continue to Grow in Colorectal Cancer

Overall, incidence and mortality rates in colorectal cancer have declined, but racial disparities continue to widen. Medscape Medical News

Gaps in Medicaid Coverage Linked to Increased Hospitalizations

SAN FRANCISCO (MedPage Today) — Interrupting Medicaid coverage is likely to aggravate conditions and relegate patients to high-cost hospitalizations they would not otherwise have needed, a retrospective cohort study showed.

University of Denver uses ‘gross’ messaging to increases handwashing, fight Norovirus

(University of Denver) Research conducted by University of Denver Associate Professor Renée Botta suggests that it takes “gross” messaging to get undergraduate students to wash their hands more frequently after going to the bathroom.

Church effort sharply increases first-time African-American blood donors

(Washington University School of Medicine) A program at Washington University School of Medicine in St. Louis and St. Louis Children’s Hospital designed to increase awareness about sickle cell disease and the importance of blood donations within the African-American faith community led to a 60 percent increase in first-time blood donations, a new study has found.

Newly discovered esophagus stem cells grow into transplantable tissue, Penn study finds

(University of Pennsylvania School of Medicine) Researchers at the University of Pennsylvania School of Medicine have discovered stem cells in the esophagus of mice that were able to grow into tissue-like structures and when placed into immune-deficient mice were able to form parts of an esophagus lining.