Treatment for HBV infection with entecavir followed by lamivudine results in virologic rebound

A two-year trial of entecavir followed by lamivudine (LAM) in patients with chronic B virus (HBV) infection resulted in a virologic rebound rate of 24% and 12% -resistance rate. Patients who continued on entecavir therapy throughout the study period had undetectable HBV at the two-year endpoint. Details of this trial are published in the April issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.


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