New report on CNS, metabolic, immunologic disorders, infection, cardiovascular disease and oncology therapeutic markets

Reportlinker.com announces that a new market research report is available in its catalogue: Drug Discovery and Preclinical Molecules by Therapy Area - Innovation Focuses on Stem Cell Therapies and Gene Therapies

IL-1 gene inactivation may reduce severe clinical complications of atherosclerosis

Atherosclerosis is a disease of the major arterial blood vessels. It is one of the major causes of heart attack and stroke. The proinflammatory molecule IL-1 has been linked to atherosclerosis and a clinical trial has been launched in which an antibody specific for IL-1-beta is being studied for its effects on the severe clinical [...]

New Light On Medicinal Benefits Of Plants

Scientists are about to make publicly available all the data they have so far on the genetic blueprint of medicinal plants and what beneficial properties are encoded by the genes identified. The resources, follow a $6 million initiative to study how plant genes contribute to producing various chemical compounds, some of which are medicinally [...]

Vorinostat in addition to chemotherapy drugs improves remission rates in AML patients

Adding a drug that activates genes to frontline combination therapy for acute myeloid leukemia resulted in an 85 percent remission rate after initial treatment, researchers at The University of Texas MD Anderson Cancer Center reported at the 53rd Annual Meeting of the American Society of Hematology.

Aging Human Bodies And Aging Human Oocytes Run On Different Clocks

Reproductive and somatic aging use different molecular mechanisms that show little overlap between the types of genes required to keep oocytes healthy and the genes that generally extend life span, according to Coleen Murphy, Ph.D., of Princeton University, who described her new findings on oocyte aging at the American Society for Cell Biology Annual Meeting [...]

Rare Gene Variants Critical For Personalized Drug Treatment Discovered By Pharmacogenomics Study

The use of genetic tests to predict a patient’s response to drugs is increasingly important in the development of personalized medicine. But genetic tests often only look for the most common gene variants…

Enrollment complete in Ceregene’s CERE-120 Phase 2b trial for Parkinson’s

Ceregene, Inc. reported today that it has completed enrollment in its Phase 2b trial of CERE-120, a gene therapy product expressing the neurturin (NRTN) gene for the treatment of Parkinson’s disease.

Improving IVF Success By Increasing Uterine Expression Of Developmental Genes

New research in Developmental Cell suggests that increasing expression of certain developmental genes at precise times in the uterus might improve pregnancy rates from in vitro fertilization-embryo transfers (IVF-ET), which remain low at around 30 percent. Conducted by researchers at Cincinnati Children’s Hospital Medical Center, the study was published online by the journal on Nov. [...]

Amplification of ALK gene may drive rapid breast cancer metastasis

Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers, may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience.

Combination of azacitidine and entinostat shows promise against NSCLC

A new type of therapy aimed at reversing the gene-silencing that promotes cancer-cell growth has shown promising results in a small clinical trial conducted by researchers at the Johns Hopkins Kimmel Cancer Center.