Isis Pharmaceuticals, Inc. announced today results from a Phase 1 study with ISIS-TTRRx. The results demonstrated that treatment with ISIS-TTRRx produced dose-dependent statistically significant reductions of greater than 80 percent in transthyretin (TTR) protein.
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Baxter International Inc. today announced the dosing of the first patients in a Phase I clinical trial of its lead investigational candidate, BAX 855, a longer-acting (PEGylated) form of a full-length recombinant factor VIII (rFVIII) protein.
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Excessive food intake, rather than the mix of protein, fat, and carbohydrates, has been implicated in causing obesity, and is key in treating it. Medscape Medical News
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A phase II clinical trial found that rilonacept, an inhibitor of the protein interleukin-1 (IL-1), significantly reduced acute gout flares that occur when initiating uric acid-lowering therapy. Results of the trial—the first placebo-controlled study investigating IL-1 targeted therapy in prevention of gout flares—show rilonacept to be generally well tolerated with no serious infections or treatment-related [...]
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(MedPage Today) — Eating too much guarantees that your body will pack on the fat, regardless of how much protein you consume, researchers found.
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(MedPage Today) — Tiny biodegradable needles made of silk protein may one day deliver ouchless injections, researchers suggested. Also in this week’s Lab Notes installment: stem cell wrapping to slow brain cancer.
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(MedPage Today) — The FDA has lifted some of the restrictions in its black box warning on echocardiography contrast agents perflutren lipid microspheres (Definity) and perflutren protein-type A microspheres (Optison).
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In the first clinical trial of an injectable vaccine containing trimeric HIV envelope protein (gp140) relevant to the predominant strain of HIV in Africa, researchers from four UK academic centers (St George’s University London, Imperial College, Hull York Medical School (HYMS; University of York) and the Medical Research Council Clinical Trial Unit) and from the [...]
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Many cancer therapies target specific proteins that proliferate on the outside of some cancer cells, but the therapies are imperfect and the cancer does not always respond. Since it is beneficial for doctors to know as soon as possible how a cancer is affected by treatment, researchers from Vanderbilt University are striving to design tests [...]
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Research on the same protein that was a primary mediator of the birth defects caused by thalidomide now holds hope in the battle against multiple myeloma, say Mayo Clinic researchers who presented results of several clinical trials at the 53nd annual meeting of the American Society of Hematology Dec. 10-13 in San Diego.
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