NIAID, Aeras partner for Phase II clinical trial of TB vaccine

Aeras announces today that the National Institute of Allergy and Infectious Diseases (NIAID), part of the United States National Institutes of Health (NIH), has joined as a partner for a Phase II proof-of-concept clinical trial of a tuberculosis vaccine candidate jointly developed by Aeras and Dutch biopharmaceutical company Crucell.

Cases of totally drug-resistant TB reported in India

“For the first time in India, 12 people have been detected with totally drug-resistant lung tuberculosis (TDR-TB), a condition in which patients do not respond to any TB medication” and for which the mortality rate is 100 percent, the Hindustan Times reports.

Diagnosis Of Tuberculosis Is Increased In Postpartum Women

The incidence of tuberculosis (TB) diagnosis is significantly increased in mothers postpartum, suggesting a potential new population to target for screening, according to a new UK-wide cohort study…

Shorter, effective treatment for latent TB infection

Research, led by Timothy Sterling, M.D., professor of Medicine at Vanderbilt University Medical Center, has led to an important change in CDC recommendations in the regimen for prevention of the centuries-old scourge, tuberculosis (TB).

Shorter Combo TB Regimen Matches Standard Therapy (CME/CE)

(MedPage Today) — A combination treatment for latent tuberculosis, delivered over three months, works as well as standard nine-month therapy with isoniazid, researchers reported.

DNA gyrase B could rapidly eliminate TB, shorten treatment time

In research at SRI International, scientists evaluating new drug targets against tuberculosis (TB) recently validated the preclinical effectiveness of a target that could rapidly eliminate infections and potentially shorten treatment time. The new drug target is a protein called DNA gyrase B, found in bacteria that cause TB infections.

NIAID’s ACTG and TB Alliance partner to complete moxifloxacin Phase III trial

The TB Alliance announces the launch of a collaboration with the National Institute of Allergy and Infectious Diseases’ (NIAID) AIDS Clinical Trial Group (ACTG) to conduct and help complete a Phase III clinical trial testing potentially faster-acting tuberculosis (TB) treatments.

Treating TB, HIV co-infections early, aggressively can save lives, multiple studies show

“Treating tuberculosis (TB) and HIV infections at the same time can be a challenge for patients and their doctors, but attacking both diseases early and aggressively isn’t harmful and could save the lives of those who are sickest,” according to a global study led by researchers from the University of California, San Francisco (UCSF) and [...]

Starting HIV therapy within two weeks of TB treatment increases survival by 33%

Timing is everything when treating patients with both HIV and tuberculosis. Starting HIV therapy in such patients within two weeks of TB treatment, rather than two months as is the current practice, increases survival by 33 percent, according to a large-scale clinical trial in Cambodia led by researchers at Children’s Hospital Boston and the Immune [...]

Vitamin D plays an essential role in the body’s fight against TB

Not just important for building strong bones, an international team of scientists has found that vitamin D also plays an essential role in the body’s fight against infections such as tuberculosis.